Transsphenoidal Surgery: What It Is, Who Needs It, and What to Expect

When a tumor grows on the pituitary gland, a small, pea-sized organ at the base of the brain that controls hormones. Also known as the master gland, it regulates everything from metabolism to stress and reproduction. If it gets too big, it can mess with vision, hormone levels, or even cause headaches. That’s where transsphenoidal surgery, a minimally invasive procedure to remove pituitary tumors through the nose. Also known as endonasal surgery, it avoids cutting into the skull and lets surgeons reach the tumor through the sphenoid sinus behind the nose.

This type of surgery isn’t for every brain tumor—it’s mostly used for pituitary tumors, benign growths that can overproduce hormones like cortisol or growth hormone. Also known as adenomas, they’re the most common reason for this procedure. Surgeons use tiny tools and a camera to navigate through the nasal passage, avoiding damage to surrounding brain tissue. It’s less risky than open brain surgery, often means a shorter hospital stay, and most people go home within a day or two. But it’s not simple—it requires a skilled neurosurgery, specialized medical field focused on treating conditions of the nervous system. Also known as brain surgery, it’s the only type of care qualified to perform this delicate operation. Not every hospital offers it, so patients often travel to centers with experienced teams.

People who need this surgery usually have symptoms like vision loss, unexplained weight gain, irregular periods, or extreme fatigue. Blood tests and MRIs confirm the tumor and its hormone activity. After surgery, hormone levels are monitored closely—some people need replacement therapy if the gland was damaged. Recovery is quick compared to open surgery, but you still need to avoid heavy lifting and blowing your nose for weeks. The success rate is high for small tumors, and many patients see their symptoms improve within days.

The posts below cover real-world stories and medical details that connect to transsphenoidal surgery—from hormone imbalances and pituitary disorders to how medications interact with recovery and what to expect during follow-up care. You’ll find info on how tumors affect daily life, how treatments like hormone therapy fit in, and how to manage side effects after surgery. Whether you’re a patient, caregiver, or just curious, these articles give you practical, no-fluff answers.